In pregnancy, reduced doses of drugs are required to induce and maintain both general and regional anaesthesia.

• Minimal Alveolar Concentration (MAC) for inhaled agents is typically reduced by about 30%
• The induction dose required for intravenous induction agents is also reduced
• Less local anaesthetic is required for regional anaesthesia. From the late first trimester onwards, a dose reduction of approximately 30% is required to achieve a given effect