Question 3

With regard to the nicotinic receptors:

Select true or false for each option, then select Submit.

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A. False. Receptors are situated only in the alpha (α) subunits. Both need to have a molecule of acetylcholine on the binding site for the receptor to open.

B. True. They have a molecular weight of 40 000 Da. The beta (β) delta (δ) and epsilon (ε) subunits are larger.

C. False. Most receptors are found in the post-synaptic membrane, in crests which overlap the presynaptic active zones.

D. False. Choline acetyltransferase is the enzyme responsible for the synthesis of acetylcholine. Acetylcholine is broken down by cholinesterase.

E. True. Incoming action potentials open voltage-gated Ca²⁺ channels, which trigger release of ACh from the vesicles.

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